203 papers
A study of 447 hospitalized patients in Reunion Island (2020–2022) suggests that a specific genetic cluster of dengue virus serotype 1, distinct from other co-circulating strains, may be responsible for the rare ocular complications observed during the outbreak.
This experimental hut trial in Benin demonstrated that the transfluthrin-based spatial emanator Mosquito Shield™ significantly reduces landing, blood-feeding, and survival of pyrethroid-resistant *Anopheles gambiae* s.l. and *Mansonia africana*, supporting its potential as a complementary malaria control tool for WHO prequalification.
This study estimates that seasonal influenza vaccination reduced the risk of fatal influenza by approximately 80% among children aged 6 months to 17 years from the 2016-2017 through 2024-2025 seasons, with high effectiveness observed in both those with and without underlying medical conditions.
This study demonstrates that the 2025-2026 H3N2 vaccine elicits cross-reactive neutralizing antibodies primarily targeting conserved antigenic sites A, D, and E on the hemagglutinin protein, which explains its moderate effectiveness against the antigenically drifted subclade K variant despite the emergence of new mutations in other epitopes.
Using two complementary high-throughput proteomics platforms on early febrile phase plasma samples, researchers identified 23 differentially expressed proteins, many of liver origin, that serve as potential early predictive biomarkers for dengue-associated plasma leakage.
This study validates a rapid, cost-effective 16S rRNA nanopore sequencing workflow for routine clinical bacterial identification, demonstrating high concordance with Illumina sequencing while significantly reducing turnaround time and offering a practical solution for decentralized diagnostics of low-diversity samples.
This study proposes a generalizable workflow to map fine-grained spatial colleague connectivity from Dutch registry data, demonstrating that such heterogeneous patterns significantly influence regional pandemic outbreak timing and can inform more tailored, network-targeted intervention strategies.
In a study of women with tuberculosis in Cape Town, South Africa, researchers found that while the median time to treatment initiation was short for both pregnant and non-pregnant women, pregnant women experienced statistically significant delays and a higher rate of never starting treatment, highlighting a critical need for targeted interventions to ensure timely care for this high-risk group.
This study reveals that early S1-directed, Fc-competent humoral immunity drives favorable COVID-19 outcomes, whereas severe disease is characterized by an early S2-biased antibody response with poor Fc-effector functionality and upregulated inhibitory Fc-receptor genes.
This genomic-epidemiologic study of 70 immunocompromised patients at Brigham and Women's Hospital reveals that extraintestinal *Clostridium perfringens* infections are associated with high mortality and specific virulence factors, notably a new independent link between the NagL hyaluronidase and highly morbid invasive disease.
The CHILL Study reveals that acute respiratory infections are highly prevalent among healthcare workers, with rhinovirus and influenza as primary causes, yet a significant portion of febrile employees continue to work, highlighting the urgent need for improved prevention and occupational health policies.
This 30-month genomic and epidemiologic study of a German tertiary NICU reveals that very low birth weight, specific clinical interventions, and climate factors (temperature and humidity) are the primary drivers of nosocomial wild-type *Klebsiella pneumoniae* acquisition and transmission, underscoring the need for comprehensive surveillance and risk-adapted infection control strategies.
This study evaluates the performance of UKHSA's operational multi-target respiratory forecasts for Influenza and COVID-19 hospital admissions in England during the 2024-25 winter, utilizing sub-ensemble simulations, generalized additive models, and Pareto analysis to quantify individual model contributions and reveal trade-offs between optimizing absolute count accuracy and trend direction.
This study developed and validated a novel dynamic scoring system based on time-dependent clinical indicators that effectively stratifies Severe Fever with Thrombocytopenia Syndrome patients into low, intermediate, and high-risk groups for precise severity quantification and early intervention.
This paper presents a newly developed, open-access Shiny-based cost comparison tool demonstrating that implementing lower-cost near point-of-care molecular tests as the initial tuberculosis diagnostic can achieve ambitious testing targets at roughly the same cost as current low-complexity automated nucleic acid amplification tests, thereby enabling significant budget savings and improved global access to rapid TB diagnosis.
A major measles epidemic in Jalisco, Mexico, during January and February 2026 was characterized by vigorous sustained transmission with an effective reproduction number of 3.34, a 6.3-day doubling time, and disproportionately high incidence among infants and young adults.
Despite concerns regarding antigenic drift in H3N2 subclade K viruses during the 2025/2026 season, this study demonstrates that seasonal vaccination in adults effectively boosts cross-reactive antibody responses with minimal evidence of antigenic drift, contradicting previous ferret-based predictions.
This case report documents a 330-day persistent SARS-CoV-2 infection in an immunocompromised patient that resulted in the accumulation of 40 viral mutations, including two characteristic of cryptic lineages, underscoring the risk of novel variant emergence in this vulnerable population.
A modeling study in Japan suggests that while both year-round and seasonal catch-up immunization strategies using maternal RSVpreF vaccines or nirsevimab monoclonal antibodies could substantially reduce infant RSV hospitalizations compared to current high-risk-only protocols, the optimal approach depends on the predictability of seasonal circulation and the duration of protection provided by the interventions.
This observational study conducted in Chittagong, Bangladesh, during the 2025 dengue outbreak describes the clinical presentation, laboratory findings, and favorable outcomes of 14 patients diagnosed with dengue-induced hemophagocytic lymphohistiocytosis (HLH), highlighting the condition's association with specific serotype patterns and the importance of early detection.